![]() ![]() ![]() The control group (n = 8) underwent the same procedure except for ablation. Then animals in the RSD group (n = 8) underwent radiofrequency ablation of the renal sympathetic nerve. To establish a hyper-sympathetic tone canine model of AF, sixteen dogs were subjected to stimulation of left stellate ganglion (LSG) and rapid atrial pacing (RAP) for 3 hours. The aim of this study was to identify the effects of RSD on AF inducibility induced by hyper-sympathetic activity in a canine model. Renal sympathetic denervation (RSD) decreases sympathetic renal afferent nerve activity, leading to decreased central sympathetic drive. ![]() Sympathetic activity involves the pathogenesis of atrial fibrillation (AF). RSG is mainly associated with AF originating from RA, LSG is mainly associated with AF originating from LA and PV. The inhibition sympathetic nerve activation by unilateral stellate ganglionectomy can reduce the AF initiating and sustaining. Stellate ganglion stimulation promote AF induction and prolong AF maintenance in atrial and pulmonary sites. Compared with LSG stimulation, left stellate ganglionectomy can markly shorten AF duration of LA, LSPV and LIPV((92.44☑.91)s vs (30.47±5.25)s, p<0.05 (81.72☓.03)s vs (38.32±4.12)s, p<0.05 (66.39±4.76)s vs (33.45☓.11)s, p<0.05), but it didn't shorten AF duration of RA.Ĭonclusions Unilateral stellate ganglion electrical stimulation plus rapid atrial pacing for 6 h can successfully establish canine model of acute AF mediated by sympathetic nerve. Compared with RSG stimulation, right stellate ganglionectomy can markly shorten AF duration of RA ((76.47☒.23)s vs (25.12±4.67)s, p<0.05), but it didn't shorten AF duration of LA, LSPV and LIPV. However, there was no significant changes in RA sites. However, there was no significant changes in LA, LSPV and LIPV sites. (3) The effect on AF duration: In RSG group, the duration of AF was significantly prolonged in RA sites ((76.47☒.23)s vs (20.64☑.76)s, p<0.05), compared with baseline. Compared with LSG stimulation, left stellate ganglionectomy can markly decreased AF induction rate of LA, LSPV and LIPV (35.4% vs 63.0%, p<0.05 39.6% vs 70.8%, p<0.05 25.0% vs 47.9%, p<0.05), but it didn't decrease the induction rate of RA. Compared with RSG stimulation, right stellate ganglionectomy can markly decrease AF induction rate of RA (31.3% vs 73.3%, p<0.05), but it didn't decrease the induction rate of LA, LSPV and LIPV. In LSG group, the induction rate of AF was significantly increased (63.0% vs 27.10%, p< 0.05 70.8% vs 33.30%, p<0.05 47.9% vs 18.80%, p<0.05), compared with baseline in LA, LSPV and LIPV respectively. (2) The effect on AF inducibility: In RSG group, the induction rate of AF was significantly increased in RA sites (73.30% vs 25.00%, p<0.05), compared with baseline. The methods were relatively simple and repeatable. Results (1) We successfully established canine models of acute AF induced by increased sympathetic nerve activity. AF induction rate, and AF duration in left atrium (LA), right atrium (RA), left superior pulmonary vein (LSPV) and left inferior pulmonary vein (LIPV) sites were measured. LSG group (n=6) underwent 6-h left stellate ganglion (LSG) electrical stimulation plus rapid atrial pacing. RSG group (n=6) underwent 6-h right stellate ganglion (RSG) stimulation plus rapid atrial pacing. Control group (n=4) underwent 6-h rapid atrial pacing only. Methods Sixteen adult mongrel dogs weighing 18 to 25 kg were randomly divided into 3 groups. Objectives To build the methodology of acute animal model of atrial fibrillation (AF) induced by increased sympathetic nerve activity. ![]()
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